Glucosamine is the ingredient contained in the shell of a crab or a shrimp. Moreover, a bone, the skin, etc. are widely distributed in the body. The cartilage which entrusts the cushion between frames will become smooth, and will solve an indirect problem, when many Glucosamine are in the inside of the body. Chondroitin is the ingredient which gives grace to a cartilage. Moreover, if it becomes together with Glucosamine, the result depended on an indirect problem improvement will be proved. Chondroitin is safe materials. MSM is what took the initial of the methane of MECHIRU SURUFONIRU, and is the organic sulfur compound which naturally exists. It is indispensable ingredient recovery for reproduction of a cartilage.